Tentative Program - Epigenetics Congress 2018

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Consumption of Tea leads to Epigenetic changes in women

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It is well-known that our surroundings and lifestyle factors, like food selections, smoking, and exposure to chemicals, will cause epigenetic changes. In the current study, researchers from Uppsala University together with research teams around Europe investigated that coffee and tea consumption might cause epigenetic changes. Previous studies have advised that both coffee and tea play a vital role in modulating disease-risk in humans by suppressing tumor progression, decreasing inflammation and influencing estrogen metabolism, mechanisms which will be mediated by epigenetic changes. The results show that there are epigenetic changes in ladies consuming tea, however not in men. Curiously, several of those epigenetic changes were found in genes concerned in cancer and estrogen metabolism. "Previous studies have shown that tea consumption reduces estrogen levels that highlight a possible distinction between the biological response to tea in men and ladies. Weronica Ek, a
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Brain development controlled by epigenetic factor

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McGill researchers have discovered, for the first time, the importance of a key epigenetic regulator within the development of the hippocampus, a component of the brain related to learning, memory, and neural stem cells. An epigenetic regulator modifies the way specific genes perform while not fixing their deoxyribonucleic acid sequence. By operating with mutant mice as models, the analysis team, led by a professor. Xiang-Jiao Yang, of McGill's Goodman Cancer Center & Department of Medicine, McGill University health center, was able to link the importance of a particular epigenetic regulator called BRPF1 to the healthy development of a section within the hippocampus known as the dentate gyrus. This discovery sheds light on however epigenetic management and neural stem cells could also be concerned in regulation human brain development, and has implications for intellectual incapacity in human patients, in addition as for medical disorders like Alzheimer's disease}
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Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains

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The promoters of mammalian genes are usually regulated by multiple distal enhancers that physically act inside distinct chromatin domains. However such domains form and the way the regulatory components within them act in single cells isn't understood. To deal with this we tend to developed Tri-C , a new chromosome conformation capture (3C) approach, to characterize concurrent chromatin interactions at individual alleles. Analysis by Tri-C identifies heterogeneous patterns of single-allele interactions between CTCF boundary components, indicating that the formation of chromatin domains probably results from a dynamic method. Inside these domains, we tend to observe specific higher-order structures that involve concurrent interactions between multiple enhancers and promoters. Such regulative hubs offer a structural basis for understanding, however, multiple cis-regulatory elements act along to determine robust regulation of gene expression. For more:  https://epigenetics.
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