Tentative Program - Epigenetics Congress 2018

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Brain development controlled by epigenetic factor

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McGill researchers have discovered, for the first time, the importance of a key epigenetic regulator within the development of the hippocampus, a component of the brain related to learning, memory, and neural stem cells. An epigenetic regulator modifies the way specific genes perform while not fixing their deoxyribonucleic acid sequence. By operating with mutant mice as models, the analysis team, led by a professor. Xiang-Jiao Yang, of McGill's Goodman Cancer Center & Department of Medicine, McGill University health center, was able to link the importance of a particular epigenetic regulator called BRPF1 to the healthy development of a section within the hippocampus known as the dentate gyrus. This discovery sheds light on however epigenetic management and neural stem cells could also be concerned in regulation human brain development, and has implications for intellectual incapacity in human patients, in addition as for medical disorders like Alzheimer's disease} ...
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Consumption of Tea leads to Epigenetic changes in women

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It is well-known that our surroundings and lifestyle factors, like food selections, smoking, and exposure to chemicals, will cause epigenetic changes. In the current study, researchers from Uppsala University together with research teams around Europe investigated that coffee and tea consumption might cause epigenetic changes. Previous studies have advised that both coffee and tea play a vital role in modulating disease-risk in humans by suppressing tumor progression, decreasing inflammation and influencing estrogen metabolism, mechanisms which will be mediated by epigenetic changes. The results show that there are epigenetic changes in ladies consuming tea, however not in men. Curiously, several of those epigenetic changes were found in genes concerned in cancer and estrogen metabolism. "Previous studies have shown that tea consumption reduces estrogen levels that highlight a possible distinction between the biological response to tea in men and ladies. Weronica Ek, a ...
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Short-term changes in DNA methylation caused by exercise and gene expression in muscle tissue that may have implications for type 2 diabetes

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Exercise will delay the onset of diabetes by boosting the expression of genes concerned in muscle oxidization and glucose regulation. A brand new study, revealed nowadays in Cell Metabolism, suggests that DNA methylation drives a number of these changes, which they will occur within some hours of exercise, providing a possible mechanism for a way exercise protects the body from metabolic disease. “It’s one of the primary studies that actually prove that DNA methylation will have an effect on things in a very short timeframe. Individuals with type 2 of diabetes are less attentive to insulin than healthy people, and therefore have difficulties maintaining normal blood glucose levels. Certain metabolic genes, like those concerned in glucose transport and mitochondrial regulation, are shown to be expressed at lower levels in diabetics, probably explaining their reduced insulin responsiveness. “Exercise is one therapeutic to take care of sensitivity of the organs to insulin and stop diab...
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