Passing stress from one generation to the next

Our life experiences may be passed on to the next generation. Researches on survivors of traumatic events have suggested that exposure to stress may indeed have lasting effects on subsequent generations. Researchers are preoccupied with however the results of stress, trauma, and different environmental exposures are passed from one generation to the next for years. Short sequences of RNA that regulate the expression of genes (small RNA molecules) are among the key factors concerned in mediating this type of inheritance. Dr. Rechavi and his team had antecedently identified a "small RNA inheritance" mechanism through that RNA molecules created a response to the requirements of specific cells and how they were regulated between generations.
Previously it is shown that worms inherited small RNAs following the starvation and viral infections of their parents. A mechanism that amplified heritable small RNAs across generations is also identified, so the response was not diluted. We also find that the Enzymes called RdRPs are required for re-creating new small RNAs to keep the response going in subsequent generations. Most inheritable epigenetic responses in C.elegans worms were found to persist for only some generations. This created the idea that epigenetic effects merely "petered out" over time, through a method of dilution or decay.

But this assumption unheeded the chance that this method does not merely die out, however, is regulated instead, said Dr. Rechavi, who in this study treated C.elegans worms with small RNAs that concentrate on the GFP (green fluorescent protein), a reporter gene normally utilized in experiments. "By following heritable small RNAs that regulated GFP -- that 'silenced' its expression -- we discovered an active, tuneable inheritance mechanism that may be turned 'on' or ‘off’. The scientists discovered that specific genes, that they named "MOTEK" (Modified Transgenerational Epigenetic Kinetics), were concerned with turning on and off epigenetic transmissions. We discovered the way to manipulate the transgenerational period of epigenetic inheritance in worms by switching 'on' and 'off' the small RNAs that worms use to manage genes, said Dr. Rechavi. These switches are controlled by a feedback interaction between gene-regulating small RNAs, that are inheritable, and therefore the MOTEK genes that are needed to produce and transmit these small RNAs across generations.

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