Posts

Brain development controlled by epigenetic factor

Image
McGill researchers have discovered, for the first time, the importance of a key epigenetic regulator within the development of the hippocampus, a component of the brain related to learning, memory, and neural stem cells. An epigenetic regulator modifies the way specific genes perform while not fixing their deoxyribonucleic acid sequence. By operating with mutant mice as models, the analysis team, led by a professor. Xiang-Jiao Yang, of McGill's Goodman Cancer Center & Department of Medicine, McGill University health center, was able to link the importance of a particular epigenetic regulator called BRPF1 to the healthy development of a section within the hippocampus known as the dentate gyrus.
This discovery sheds light on however epigenetic management and neural stem cells could also be concerned in regulation human brain development, and has implications for intellectual incapacity in human patients, in addition as for medical disorders like Alzheimer's disease} and alter…

Consumption of Tea leads to Epigenetic changes in women

Image
It is well-known that our surroundings and lifestyle factors, like food selections, smoking, and exposure to chemicals, will cause epigenetic changes. In the current study, researchers from Uppsala University together with research teams around Europe investigated that coffee and tea consumption might cause epigenetic changes. Previous studies have advised that both coffee and tea play a vital role in modulating disease-risk in humans by suppressing tumor progression, decreasing inflammation and influencing estrogen metabolism, mechanisms which will be mediated by epigenetic changes.

The results show that there are epigenetic changes in ladies consuming tea, however not in men. Curiously, several of those epigenetic changes were found in genes concerned in cancer and estrogen metabolism. "Previous studies have shown that tea consumption reduces estrogen levels that highlight a possible distinction between the biological response to tea in men and ladies. Weronica Ek, a researcher …

Short-term changes in DNA methylation caused by exercise and gene expression in muscle tissue that may have implications for type 2 diabetes

Image
Exercise will delay the onset of diabetes by boosting the expression of genes concerned in muscle oxidization and glucose regulation. A brand new study, revealed nowadays in Cell Metabolism, suggests that DNA methylation drives a number of these changes, which they will occur within some hours of exercise, providing a possible mechanism for a way exercise protects the body from metabolic disease. “It’s one of the primary studies that actually prove that DNA methylation will have an effect on things in a very short timeframe. Individuals with type 2 of diabetes are less attentive to insulin than healthy people, and therefore have difficulties maintaining normal blood glucose levels. Certain metabolic genes, like those concerned in glucose transport and mitochondrial regulation, are shown to be expressed at lower levels in diabetics, probably explaining their reduced insulin responsiveness. “Exercise is one therapeutic to take care of sensitivity of the organs to insulin and stop diabet…

Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains

Image
The promoters of mammalian genes are usually regulated by multiple distal enhancers that physically act inside distinct chromatin domains. However such domains form and the way the regulatory components within them act in single cells isn't understood. To deal with this we tend to developed Tri-C, a new chromosome conformation capture (3C) approach, to characterize concurrent chromatin interactions at individual alleles. Analysis by Tri-C identifies heterogeneous patterns of single-allele interactions between CTCF boundary components, indicating that the formation of chromatin domains probably results from a dynamic method. Inside these domains, we tend to observe specific higher-order structures that involve concurrent interactions between multiple enhancers and promoters. Such regulative hubs offer a structural basis for understanding, however, multiple cis-regulatory elements act along to determine robust regulation of gene expression.

For more: https://epigenetics.geneticconfe…

Histone Modification Landscape Pristine

Image
Recycling represents one in every of the foremost necessary ways to keep the earth clean and green for generations to come back. Used paper, metal, and plastic and alternative different detritus typically encounter the second use, however, will we have a tendency to recycle the histone proteins that facilitate to package our DNA and maintain cell-type-specific transcriptional programs? A lean, clean, and green team led by Anja Groth (University of Copenhagen, Denmark) couldn´t let such a tantalizing question goes to “waste”, and then they developed a brand new genome-wide technique (ChOR-seq) to investigate chromatin occupancy after DNA replication by next-generation sequencing. ChOR-seq tracks usage of “old” histones and directly measures the replication-dependent displacement of pre-existing histone modifications by using a combination of pulse labeling of replicating DNA with a nucleotide analog and also the data that recently synthesized histones lack tri-methylation modifications…

LIF Gene in Elephants Is Upregulated by TP53 to Induce Apoptosis in Response to DNA Damage

Image
In the current issue of Cell Reports Dr. Vazquez and collaborators give molecular proof for an evolutionary mechanism developed in giant body size and long lifetime mammals that protects cells from cancer progression through apoptosis. The multifunctional interleukin-6 category cytokine leukemia inhibitory factor (LIF), as an example, will perform as either a growth suppressor or an oncogene, counting on the context, and induce caspase-induced apoptosis through an unknown mechanism. By finding out LIF duplications in fifty-three mammalian genomes, researchers were ready to determine that an elephant pseudogene referred to as LIF6 was transcribed and fully functional (zombie gene) in response to DNA harm. LIF6 is upregulated, Induces Mitochondrial dysfunction and Caspase-Dependent apoptosis viaTP53 signaling and translocated to mitochondria. More exactly upon DNA harm TP53 binds LIF6 and upregulates its transcription.

For more: https://epigenetics.geneticconferences.com/
Image
Primary constitutional MLH1 Epimutations Lynch syndrome (LS) is characterized by an enhanced risk for colorectal cancer (CRC) and cancers of the ovary, stomach, intestine, endometrium, hepatobiliary tract, brain, skin and urinary tract. LS is caused by a germline genetic variant among a mismatch repair (MMR) gene, MLH1 (MutL homolog 1), MSH2 (MutS Homolog 2), MSH6 (MutS homolog 6) or PSM2 (PMS1 Homolog 2), or a terminal deletion of EPCAM (Epithelial Cell Adhesion Molecule gene) with resulting epigenetic inactivation of MSH2. In a very little proportion of LS patients, the cancer predisposition is caused by a constitutional epimutation of MLH1, within which one allele of the CpG island promoter is aberrantly hypermethylated throughout traditional tissues with associated loss-of-expression from this allele. Two forms of constitutional MLH1 epimutation are defined: secondary, that are coupled in-cis to a genetic alteration associated follow a chromosome dominant pattern of inheritance3,4,5…