LIF Gene in Elephants Is Upregulated by TP53 to Induce Apoptosis in Response to DNA Damage

In the current issue of Cell Reports Dr. Vazquez and collaborators give molecular proof for an evolutionary mechanism developed in giant body size and long lifetime mammals that protects cells from cancer progression through apoptosis. The multifunctional interleukin-6 category cytokine leukemia inhibitory factor (LIF), as an example, will perform as either a growth suppressor or an oncogene, counting on the context, and induce caspase-induced apoptosis through an unknown mechanism. By finding out LIF duplications in fifty-three mammalian genomes, researchers were ready to determine that an elephant pseudogene referred to as LIF6 was transcribed and fully functional (zombie gene) in response to DNA harm. LIF6 is upregulated, Induces Mitochondrial dysfunction and Caspase-Dependent apoptosis viaTP53 signaling and translocated to mitochondria. More exactly upon DNA harm TP53 binds LIF6 and upregulates its transcription.


For more: https://epigenetics.geneticconferences.com/

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