Histone Modification Landscape Pristine


Recycling represents one in every of the foremost necessary ways to keep the earth clean and green for generations to come back. Used paper, metal, and plastic and alternative different detritus typically encounter the second use, however, will we have a tendency to recycle the histone proteins that facilitate to package our DNA and maintain cell-type-specific transcriptional programs? A lean, clean, and green team led by Anja Groth (University of Copenhagen, Denmark) couldn´t let such a tantalizing question goes to “waste”, and then they developed a brand new genome-wide technique (ChOR-seq) to investigate chromatin occupancy after DNA replication by next-generation sequencing. ChOR-seq tracks usage of “old” histones and directly measures the replication-dependent displacement of pre-existing histone modifications by using a combination of pulse labeling of replicating DNA with a nucleotide analog and also the data that recently synthesized histones lack tri-methylation modifications at the time of deposition. Using this newly developed approach, the team currently demonstrates that our cells will indeed recycle their histone proteins throughout DNA replication to keep their histone modification landscapes during a pristine condition for generations to come! Moreover, this eco-friendly study additionally suggests that the incorporation and modification of recent histone proteins might induce epigenome fluctuations across the cell cycle that underlies cellular heterogeneity.


For more:  https://epigenetics.geneticconferences.com/

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