Use of Smartphone for detecting the Breast Cancer

With increasing demand and pressure on healthcare budgets, progressive initiatives are being taken to form healthcare a lot of patient-centered, reliable, accessible and cheap. Point-of-care devices became an efficient and possible manner for individuals to watch their own health, as against waiting weeks for costly test results. Seeing the various POC devices that exist already for diabetes, maternity and other health conditions, LSU mechanical engineering assistant professor Manas Gartia puzzled why there could not be one for breast cancer genetic testing. "Breast cancer is that the second commonest cancer in ladies within the United States," Gartia said. In 2015, 41,523 ladies died of breast cancer in the U.S., with 3,523 of these in Louisiana. We tend to believe that early detection saves lives. That’s why genetic testing is thus standard. Individuals wish to catch it [cancer] before it's found in an exceeding mammogram. Gartia and his team of researchers have created an accessible method for ladies – and men – to check for the "Breast Cancer gene one," additional usually referred to as BRCA1. If the test comes back positive, it suggests that there's a mutation within the BRCA1 sequence and, therefore, a way higher risk of developing breast or ovarian cancer in ladies and pancreatic cancer in men.


According to the Maurer Foundation, almost 60 % of ladies who inherit the harmful mutation can develop breast cancer. However, not all breast cancer is thanks to this genetic mutation and not all ladies or men with the mutation can develop breast cancer. They selected the BRCA1 gene because of its high prevalence in half the worldwide population, and second, as a result of plenty of researched knowledge regarding the alterations and mutations are accessible at the gene level from varied databases. Rather than pay money for a home test kit, which might still need a doctor's visit for a proof, or head to the doctor, wherever the wait time for results may be many weeks and price thousands of bucks, Gartia proposes doing a DNA microarray analysis employing a smartphone and moveable visible light microarray-based imaging system known as the FluoroZen, that provides leads to twenty minutes.
The FluoroZen works by analyzing DNA – saliva or blood – that's placed on nitrocellulose or NC paper that is then assault a glass slide holder. The FluoroZen detects the fluorescent oligonucleotide spots on the NC paper using 2 light spectrum filters – one to excite the fluorescent dye and therefore the second to capture the spectrum. The spots with higher intensity are brighter, indicating the presence of the mutated BRCA1 gene. A smartphone that is connected to the POC device then shows the results (a simple yes or NO) on the screen when taking an image of the spots.

 For more: https://epigenetics.geneticconferences.com/

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